An aldose reductase inhibitor (IC50 = 35 nM for the bovine lens enzyme); dietary administration decreases sciatic nerve galactitol accumulation in a rat model of galactosemia (ED50 = 7.3 mg/kg) and sciatic nerve sorbitol accumulation (ED50 = 4.8 mg/kg per day) in a rat model of STZ-induced diabetes; decreases urinary total protein excretion in STZ-induced diabetic rats at 25 mg/kg per day; decreases levels of galactitol in the lens of and inhibits cataract formation in rats fed a high-galactose diet when applied topically at 2 and 3% in 10 μl four times per day

Tolrestat – 5 mg

Brand:
Cayman
CAS:
82964-04-3
Storage:
-20
UN-No:
Non-Hazardous - /

Tolrestat is an aldose reductase inhibitor (IC50 = 35 nM for the bovine lens enzyme).{46762} Dietary administration of tolrestat decreases sciatic nerve galactitol accumulation in a rat model of galactosemia (ED50 = 7.3 mg/kg per day) and sciatic nerve sorbitol accumulation (ED50 = 4.8 mg/kg per day) in a rat model of diabetes induced by streptozotocin (STZ; Item No. 13104). It also decreases urinary total protein exretion in a rat model of STZ-induced diabetes when administered at a dose of 25 mg/kg per day.{46764} Topical administration of tolrestat (2 and 3% in 10 μl four times per day) decreases levels of galactitol in the lens of and inhibits cataract formation in rats fed a high-galactose diet.{46763}  

 

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Description

An aldose reductase inhibitor (IC50 = 35 nM for the bovine lens enzyme); dietary administration decreases sciatic nerve galactitol accumulation in a rat model of galactosemia (ED50 = 7.3 mg/kg) and sciatic nerve sorbitol accumulation (ED50 = 4.8 mg/kg per day) in a rat model of STZ-induced diabetes; decreases urinary total protein excretion in STZ-induced diabetic rats at 25 mg/kg per day; decreases levels of galactitol in the lens of and inhibits cataract formation in rats fed a high-galactose diet when applied topically at 2 and 3% in 10 μl four times per day

Formal name: N-[[6-methoxy-5-(trifluoromethyl)-1-naphthalenyl]thioxomethyl]-N-methyl-glycine

Synonyms:  AY 27773

Molecular weight: 357.3

CAS: 82964-04-3

Purity: ≥98%

Formulation: A crystalline solid

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