A saponin; decreases serum total cholesterol

Notoginsenoside R1 – 25 mg

Brand:
Cayman
CAS:
80418-24-2
Storage:
-20
UN-No:
Non-Hazardous - /

Notoginsenoside R1 is a saponin that has been found in P. notoginseng and has diverse biological activities, including cardioprotective, neuroprotective, and anti-inflammatory properties.{48858} It decreases serum total cholesterol, triacylglycerol, and oxidized LDL (oxLDL) levels, as well as reduces atherosclerotic lesion area and lipid deposition in the aortic root of ApoE-/- mice fed a Western diet when administered at a dose of 25 mg/kg per day for eight weeks.{48859} Notoginsenoside R1 (100 mg/kg) inhibits apoptosis of hippocampal neurons and reduces infarct size in a rat model of cerebral ischemia-reperfusion injury induced by bilateral common carotid artery occlusion.{48860} It decreases colonic NF-ĸB and myeloperoxidase (MPO) activities and TNF-α and IL-6 levels, as well as reduces colonic shortening, tissue damage, and inflammatory cell infiltration in a mouse model of colitis induced by dextran sulfate sodium (DSS; Item No. 23250) when administered at a dose of 25 mg/kg per day for seven days.{48861}  

 

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SKU: 29691 - 25 mg Category:

Description

A saponin; decreases serum total cholesterol, triacylglycerol, and oxLDL levels, as well as reduces atherosclerotic lesion area and lipid deposition in the aortic root of ApoE-/- mice fed a Western diet at 25 mg/kg per day for 8 weeks; inhibits apoptosis of hippocampal neurons and reduces infarct size in a rat model of cerebral ischemia-reperfusion injury induced by bilateral common carotid artery occlusion at 100 mg/kg; decreases colonic NF-ĸB and MPO activities and TNF-α and IL-6 levels, as well as reduces colonic shortening, tissue damage, and inflammatory cell infiltration in a DSS-induced mouse model of colitis at 25 mg/kg per day for 7 days

Formal name: (3β,6α,12β)-20-(β-D-glucopyranosyloxy)-3,12-dihydroxydammar-24-en-6-yl 2-O-β-D-xylopyranosyl-β-D-glucopyranoside

Synonyms:  Sanchinoside R1

Molecular weight: 933.1

CAS: 80418-24-2

Purity: ≥98%

Formulation: A crystalline solid

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