An activator of KCa2.1

SKA-31 – 25 mg

Brand:
Cayman
CAS:
40172-65-4
Storage:
-20
UN-No:
Non-Hazardous - /

SKA-31 is an activator of the small- and intermediate conductance calcium-activated potassium channels KCa2.1, KCa2.2, KCa2.3, and KCa3.1 (EC50s = 2.9, 1.9, 2.9, and 0.26 µM, respectively, in a patch-clamp assay).{52233} It also blocks the voltage-gated potassium (Kv) channels Kv1.3, Kv1.5, Kv3.1, and Kv3.2 by 10 to 30% and the voltage-gated sodium (Nav) channels Nav1.2, Nav1.4, and Nav1.5 by 9 to 40% in a panel of 13 ion channels when used at a concentration of 25 µM. SKA-31 increases vasodilation induced by acetylcholine (Item No. 23829) in isolated mouse carotid artery (EC50 = 93 nM) and induces relaxation of isolated rat mesenteric artery rings precontracted with phenylephrine (IC50 = 93 nM).{52233,52234} It decreases blood pressure in normotensive and angiotensin II-induced hypertensive mice when administered at a dose of 30 mg/kg.{52233}  

 

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SKU: 29690 - 25 mg Category:

Description

An activator of KCa2.1, KCa2.2, KCa2.3, and KCa3.1 (EC50s = 2.9, 1.9, 2.9, and 0.26 µM, respectively, in a patch-clamp assay); blocks Kv1.3, -1.5, -3.1, and -3.2 by 10-30% and Nav1.2, -1.4, and -1.5 by 9-40% in a panel of 13 ion channels at 25 µM; increases acetylcholine-induced vasodilation in isolated mouse carotid artery (EC50 = 93 nM) and induces relaxation of isolated rat mesenteric artery rings precontracted with phenylephrine (IC50 = 93 nM); decreases blood pressure in normotensive and angiotensin II-induced hypertensive mice at 30 mg/kg

Formal name: naphtho[1,2-d]thiazol-2-amine

Synonyms:  2-Aminonaphthiazole

Molecular weight: 200.3

CAS: 40172-65-4

Purity: ≥95%

Formulation: A solid

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