A GLP-1R agonist (KB = 26.3 nM for the recombinant human receptor); inhibits forskolin-induced cAMP accumulation in BHK cells expressing the recombinant human receptor (EC50 = 101 nM); increases glucose-induced insulin levels in pancreatic islets isolated from wild-type

GLP-1R Agonist DMB – 1 mg

Brand:
Cayman
CAS:
281209-71-0
Storage:
-20
UN-No:
Non-Hazardous - /

GLP-1R agonist DMB is an agonist of glucagon-like peptide 1 receptor (GLP-1R; KB = 26.3 nM for the recombinant human receptor).{46660} It inhibits forskolin-induced cAMP accumulation in BHK cells expressing the recombinant human receptor with an EC50 value of 101 nM.{46661} GLP-1R (100 and 1,000 nM) increases insulin levels induced by D-(+)-glucose (Item No. 23733) in pancreatic islets isolated from wild-type, but not Glp1r knockout, mice. It reduces fasting plasma glucose levels in mice when administered at a dose of 5 µmol/kg.{46662}  

 

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SKU: 29678 - 1 mg Category:

Description

A GLP-1R agonist (KB = 26.3 nM for the recombinant human receptor); inhibits forskolin-induced cAMP accumulation in BHK cells expressing the recombinant human receptor (EC50 = 101 nM); increases glucose-induced insulin levels in pancreatic islets isolated from wild-type, but not Glp1r knockout, mice at 100 and 1,000 nM; reduces fasting plasma glucose levels in mice at 5 µmol/kg

Formal name: 6,7-dichloro-N-(1,1-dimethylethyl)-3-(methylsulfonyl)-2-quinoxalinamine

Synonyms: 

Molecular weight: 348.2

CAS: 281209-71-0

Purity: ≥98%

Formulation: A crystalline solid

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