A terpene with diverse biological activities; inhibits COMT (Ki = 22 µM); bacteriostatic against a panel of Gram-positive and Gram-negative bacteria (MICs = 12-82 µM); bactericidal against A. hydrophilia and C. violaceum at 20 mM; an iron chelator that inhibits iron-dependent P. placenta growth at 50 µM and P. placenta degradation of pine sapwood blocks at 5 mM; inhibits LPS-induced NO production in RAW 264.7 cells (IC50 = 12 µM); reduces thyroid radioiodide uptake in rats at 0.25 mmol/animal; dietary administration induces growth retardation and hyperactivity in mice

Tropolone – 5 mg

Brand:
Cayman
CAS:
533-75-5
Storage:
-20
UN-No:
Non-Hazardous - /

Tropolone is a terpene that has been found in cupressaceous tree bark and has diverse biological activities.{52319,52320,52321,52322,52323} It inhibits catechol O-methyltransferase (COMT; Ki = 22 µM).{52319} Tropolone is bacteriostatic against a panel of Gram-positive and Gram-negative bacteria (MICs = 12-82 µM) and bactericidal against A. hydrophilia and C. violaceum when used at a concentration of 20 mM.{52320} It is an iron chelator that inhibits iron-dependent growth of the wood rot fungus P. placenta when used at a concentration of 50 µM and P. placenta degradation of pine sapwood blocks impregnated with 5 mM tropolone.{52321} It inhibits LPS-induced production of nitric oxide (NO) in RAW 264.7 cells (IC50 = 12 µM).{52322} Tropolone (0.25 mmol/animal) reduces thyroid radioiodide uptake in rats.{52323} Dietary administration of tropolone induces growth retardation and hyperactivity in mice.  

 

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Description

A terpene with diverse biological activities; inhibits COMT (Ki = 22 µM); bacteriostatic against a panel of Gram-positive and Gram-negative bacteria (MICs = 12-82 µM); bactericidal against A. hydrophilia and C. violaceum at 20 mM; an iron chelator that inhibits iron-dependent P. placenta growth at 50 µM and P. placenta degradation of pine sapwood blocks at 5 mM; inhibits LPS-induced NO production in RAW 264.7 cells (IC50 = 12 µM); reduces thyroid radioiodide uptake in rats at 0.25 mmol/animal; dietary administration induces growth retardation and hyperactivity in mice

Formal name: 2-hydroxy-2,4,6-cycloheptatrien-1-one

Synonyms:  2-Hydroxytropone|NSC 89303|Purpurocatechol|α-Tropolone

Molecular weight: 122.1

CAS: 533-75-5

Purity: ≥98%

Formulation: A solid

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