A terpene with diverse biological activities; inhibits COMT (Ki = 22 µM); bacteriostatic against a panel of Gram-positive and Gram-negative bacteria (MICs = 12-82 µM); bactericidal against A. hydrophilia and C. violaceum at 20 mM; an iron chelator that inhibits iron-dependent P. placenta growth at 50 µM and P. placenta degradation of pine sapwood blocks at 5 mM; inhibits LPS-induced NO production in RAW 264.7 cells (IC50 = 12 µM); reduces thyroid radioiodide uptake in rats at 0.25 mmol/animal; dietary administration induces growth retardation and hyperactivity in mice

Tropolone – 1 mg

Brand:
Cayman
CAS:
533-75-5
Storage:
-20
UN-No:
Non-Hazardous - /

Tropolone is a terpene that has been found in cupressaceous tree bark and has diverse biological activities.{52319,52320,52321,52322,52323} It inhibits catechol O-methyltransferase (COMT; Ki = 22 µM).{52319} Tropolone is bacteriostatic against a panel of Gram-positive and Gram-negative bacteria (MICs = 12-82 µM) and bactericidal against A. hydrophilia and C. violaceum when used at a concentration of 20 mM.{52320} It is an iron chelator that inhibits iron-dependent growth of the wood rot fungus P. placenta when used at a concentration of 50 µM and P. placenta degradation of pine sapwood blocks impregnated with 5 mM tropolone.{52321} It inhibits LPS-induced production of nitric oxide (NO) in RAW 264.7 cells (IC50 = 12 µM).{52322} Tropolone (0.25 mmol/animal) reduces thyroid radioiodide uptake in rats.{52323} Dietary administration of tropolone induces growth retardation and hyperactivity in mice.  

 

Available on backorder

Add to quotes
SKU: 29674 - 1 mg Category:

Description

A terpene with diverse biological activities; inhibits COMT (Ki = 22 µM); bacteriostatic against a panel of Gram-positive and Gram-negative bacteria (MICs = 12-82 µM); bactericidal against A. hydrophilia and C. violaceum at 20 mM; an iron chelator that inhibits iron-dependent P. placenta growth at 50 µM and P. placenta degradation of pine sapwood blocks at 5 mM; inhibits LPS-induced NO production in RAW 264.7 cells (IC50 = 12 µM); reduces thyroid radioiodide uptake in rats at 0.25 mmol/animal; dietary administration induces growth retardation and hyperactivity in mice

Formal name: 2-hydroxy-2,4,6-cycloheptatrien-1-one

Synonyms:  2-Hydroxytropone|NSC 89303|Purpurocatechol|α-Tropolone

Molecular weight: 122.1

CAS: 533-75-5

Purity: ≥98%

Formulation: A solid

Related products

  • PtdIns-(3

    PtdIns-(3,4,5)-P3-biotin (sodium salt) – 25 µg

    The PtdIn phosphates play an important role in the generation and transduction of intracellular signals.{8344,4096,14518} PtdIns-(3,4,5)-P3-biotin is an affinity probe which allows the PIP3 to be detected through an interaction with the biotin ligand. This design allows PtdIns-(3,4,5)-P3-biotin to serve as a general probe for any protein with a high affinity binding interaction with inositol-(3,4,5)-triphosphate phospholipids, such as phosphatidylinositol 3-kinase, PTEN, or PH-domain-containing proteins.  

     

    Brand:
    Cayman
    SKU:10009531 - 25 µg

    Available on backorder

    Add to quotes
    Add to quotes
    View product page
  • A powerful effector in both the TetR and revTetR transcriptional regulator systems

    Anhydrotetracycline (hydrochloride) – 50 mg

    The tetracycline repressor (TetR) is a transcriptional regulator which normally binds tightly to its palindromic tetO operator DNA, blocking gene expression.{17508} Tet causes the repressor to dissociate from the DNA, allowing transcription to occur. A novel reverse TetR (revTetR) requires tetracycline as a co-repressor to bind tetO and block transcription.{17509,17510} Anhydrotetracycline (hydrochloride) is a powerful effector in both the tetracycline repressor (TetR) and reverse TetR (revTetR) systems, binding the Tet repressor 35-fold more strongly than Tet.{17508,17511} Moreover, anhydrotetracycline poorly binds the 30S ribosomal subunit, compared to Tet,{17512} so it does not act as a general inhibitor of translation and is a poor antibiotic. Perhaps related to this, the concentration of anhydrotetracycline that inhibits eukaryotic cell growth is more than a 1,000-fold above the dose that alters transcription through TetR.{17508}  

     

    Brand:
    Cayman
    SKU:10009542 - 50 mg

    Available on backorder

    Add to quotes
    Add to quotes
    View product page
  • A potent inhibitor of Cdk2/cyclin E with an IC50 value of 0.1 µM; also inhibits Cdk7/cyclin H

    (R)-Roscovitine – 500 µg

    Cyclin-dependent kinases (CDKs) are key regulators of cell cycle progression and are therefore promising targets for cancer therapy. (R)-Roscovitine is a potent inhibitor of Cdk2/cyclin E with an IC50 value of 0.1 µM.{14988} It also inhibits Cdk7/cyclin H, Cdk5/p35, and cell division cycle (cdc)/cyclin B with IC50 values of 0.49, 0.16, and 0.65 µM, respectively.{14987,14988,14991} (R)-Roscovitine inhibits the growth of rapidly proliferating cells with an average IC50 value of 15.2 µM against a panel of 19 human tumor cell lines.{14988} In murine models of polycystic kidney disease, (R)-roscovitine effectively inhibited disease progression at doses of 50-100 mg/kg.{14564}  

     

    Brand:
    Cayman
    SKU:10009569 - 500 µg

    Available on backorder

    Add to quotes
    Add to quotes
    View product page
  • CAY10512 is a substituted trans-stilbene analog of resveratrol that is 100-fold more potent as measured by antioxidant activity. The IC50 value for inhibition of TNFα-induced activation of NF-κB by CAY10512 is 0.15 µM compared to 20 µM by resveratrol.{14545}

    CAY10512 – 100 mg

    The nuclear factor-κB (NF-κB) regulates the expression of numerous genes involved in immunity and inflammation, cellular stress responses, growth, and apoptosis. Resveratrol, a polyphenolic trans-stilbene, is a known inhibitor of the activation of NF-κB and exhibits activity against a wide variety of cancer cells. CAY10512 is a substituted trans-stilbene analog of resveratrol that is 100-fold more potent as measured by antioxidant activity. The IC50 value for inhibition of TNFα-induced activation of NF-κB by CAY10512 is 0.15 µM compared to 20 µM by resveratrol.{14545}  

     

    Brand:
    Cayman
    SKU:10009536 - 100 mg

    Available on backorder

    Add to quotes
    Add to quotes
    View product page