Description
An irreversible inhibitor of mutant EGFRs (IC50s = 1.7, 2, and 3.3 nM for EGFRL858R/T790M, EGFRDel19/T790M, and EGFRDel19, respectively); selective for mutant EGFRs over wild-type EGFR, HER2, and HER4 (IC50s = 76, 364, and 1,017 nM, respectively); reduces viability of Ba/F3 cells expressing mutant EGFRs (IC50s = 3.3-5.7 nM); reduces tumor volume in an EGFRT790M mutant H1975 NSCLC mouse xenograft model at 1, 3, and 10 mg/kg
Formal name: N-[5-[[4-[4-[(dimethylamino)methyl]-3-phenyl-1H-pyrazol-1-yl]-2-pyrimidinyl]amino]-4-methoxy-2-(4-morpholinyl)phenyl]-2-propenamide
Synonyms: YH25448
Molecular weight: 554.6
CAS: 1903008-80-9
Purity: ≥98%
Formulation: A solid
