Description
An AMPK activator (EC50 = 9 nM); selective for AMPK over a kinase panel at 10 µM, as well as CYP3A4 and CYP2D6 (IC50s = >50 µM) and PXR (EC50 = >30 µM); increases muscle and liver levels of phosphorylated ACC and reduces insulin resistance in DIO mice at 30 mg/kg; inhibits hepatic fatty acid synthesis in db/db mice
Formal name: 5-[(5-[1,1′-biphenyl]-4-yl-6-chloro-1H-benzimidazol-2-yl)oxy]-2-methyl-benzoic acid
Synonyms:
Molecular weight: 454.9
CAS: 1219737-12-8
Purity: ≥98%
Formulation: A solid
