A compound with diverse biological activities; inhibits hydrogen peroxide-induced decreases in cell viability and the levels of SOD and GPX and increases in ROS and MDA levels in HUVECs at 100 and 150 μg/ml;) inhibits PGE2 production induced by LPS and IFN-γ in primary rat glia at 50 and 100 μM; reduces infarct volume

Ligustrazine (hydrochloride) – 100 mg

Brand:
Cayman
CAS:
76494-51-4
Storage:
-20
UN-No:
Non-Hazardous - /

Ligustrazine is a compound that has been found in L. wallichii and has diverse biological activities, including antioxidant, anti-inflammatory, neuroprotective, and anticancer properties.{46728,46727,46729} It inhibits hydrogen peroxide-induced decreases in cell viability and the levels of superoxide dismutase (SOD) and glutathione peroxidase (GPX) and increases in reactive oxygen species (ROS) and malondialdehyde (MDA) levels in human umbilical vein endothelial cells (HUVECs) when used at concentrations of 100 and 150 μg/ml.{46728} Ligustrazine (50 and 100 μM) inhibits prostaglandin E2 (PGE2; Item No. 14010) production induced by LPS and IFN-γ in primary rat glia.{46727} It reduces infarct volume, cortical edema, and cortical PGE2 levels in a rat model of transient focal cerebral ischemia induced by common carotid artery and middle cerebral artery occlusion when administered at a dose of 20 mg/kg. Ligustrazine inhibits the proliferation of MG-63, Saos-2, and U2OS osteosarcoma cells (IC50s = 10.3, 24.7, and 54.7 mg/ml, respectively) in vitro and reduces tumor growth in an MG-63 mouse xenograft model when administered at a dose of 100 mg/kg every other day.{46729}  

 

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SKU: 29658 - 100 mg Category:

Description

A compound with diverse biological activities; inhibits hydrogen peroxide-induced decreases in cell viability and the levels of SOD and GPX and increases in ROS and MDA levels in HUVECs at 100 and 150 μg/ml;) inhibits PGE2 production induced by LPS and IFN-γ in primary rat glia at 50 and 100 μM; reduces infarct volume, cortical edema, and cortical PGE2 levels in a rat model of transient focal cerebral ischemia induced by common carotid artery and middle cerebral artery occlusion at 20 mg/kg; inhibits the proliferation of MG-63, Saos-2, and U2OS osteosarcoma cells (IC50s = 10.3, 24.7, and 54.7 mg/ml, respectively) in vitro; reduces tumor growth in an MG-63 mouse xenograft model at 100 mg/kg every other day

Formal name: 2,3,5,6-tetramethyl-pyrazine, hydrochloride

Synonyms:  2,3,5,6-Tetramethylpyrazine

Molecular weight: 136.2

CAS: 76494-51-4

Purity: ≥98%

Formulation: A crystalline solid

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