A fungal metabolite with anticancer activity; inhibits the growth of a variety of cancer cells

Pericosine A – 1 mg

Brand:
Cayman
CAS:
200335-68-8
Storage:
-20
UN-No:
Non-Hazardous - /

Pericosine A is a fungal metabolite that has been found in P. byssoides and has anticancer activity.{49631} It inhibits the growth of a variety of cancer cells, including breast, colon, lung, ovary, stomach, and prostate cell lines (GI50s = 0.05-24.55 µM) and increases survival in a P388 mouse xenograft model when administered at a dose of 25 mg/kg. Pericosine A inhibits EGFR by 40 to 70% when used at a concentration of 100 µg/ml. It also reacts with organosulfur compounds in skunk spray to form stable thioethers as odorless products.{49632}  

 

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Description

A fungal metabolite with anticancer activity; inhibits the growth of a variety of cancer cells, including breast, colon, lung, ovary, stomach, and prostate cell lines (GI50s = 0.05-24.55 µM); increases survival in a P388 mouse xenograft model at 25 mg/kg; inhibits EGFR by 40 to 70% at 100 µg/ml; reacts with organosulfur compounds in skunk spray to form odorless thioether products

Formal name: (3S,4S,5S,6S)-6-chloro-3,4,5-trihydroxy-1-cyclohexene-1-carboxylic acid, methyl ester

Synonyms:  (+)-Pericosine A

Molecular weight: 222.6

CAS: 200335-68-8

Purity: ≥70%

Formulation: A solid

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