An Eendogenous inhibitory amino acid; inhibits GABA uptake by mouse GAT1

Hypotaurine – 250 mg

Brand:
Cayman
CAS:
300-84-5
Storage:
-20
UN-No:
Non-Hazardous - /

Hypotaurine is an endogenous inhibitory amino acid.{45691} It inhibits GABA uptake by mouse GABA transporter 1 (GAT1), GAT2, GAT3, and GAT4 (IC50s = 170, 240, 4.9, and 8.1 μM, respectively) and rat GAT1, GAT2, and GAT3 (IC50s = 1,010, 52, and 73 μM, respectively). Hypotaurine also inhibits GABA uptake by betaine/GABA transporter 1 (BGT1) in L-M(TK-) cells expressing the human transporter (IC50 = 380 μM).{45692} It inhibits sodium-stimulated GABA uptake by rabbit choroid plexus slices (IC50 = 21.9 μM).{45693} It scavenges hypochlorous acid (HOCl) and hydroxyl, but not superoxide, radicals in cell-free assays.{45694} Hypotaurine (1 mM) protects rat TR-TBT 18d-1 placental trophoblasts from hydrogen peroxide-induced cell death.{45695}  

 

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Description

An Eendogenous inhibitory amino acid; inhibits GABA uptake by mouse GAT1, GAT2, GAT3, and GAT4 (IC50s = 170, 240, 4.9, and 8.1 μM, respectively) and rat GAT1, GAT2, and GAT3 (IC50s = 1,010, 52, and 73 μM, respectively); inhibits GABA uptake by BGT1 n L-M(TK-) cells expressing the human transporter (IC50 = 380 μM); inhibits sodium-stimulated GABA uptake by rabbit choroid plexus slices (IC50 = 21.9 μM); scavenges HOCl and hydroxyl, but not superoxide, radicals in cell-free assays; protects rat TR-TBT 18d-1 placental trophoblasts from hydrogen peroxide-induced cell death at 1 mM

Formal name: 2-amino-ethanesulfinic acid

Synonyms: 

Molecular weight: 109.1

CAS: 300-84-5

Purity: ≥95%

Formulation: A solid

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