A lipophilic derivative of ascorbic acid with antioxidant and antiproliferative activities; scavenges hydroxyl radicals in cell-free assays; reduces the rate of autoxidation of soybean

Ascorbyl Palmitate – 500 g

Brand:
Cayman
CAS:
137-66-6
Storage:
-20
UN-No:
Non-Hazardous - /

Ascorbyl palmitate is a lipophilic derivative of ascorbic acid (Item No. 14656) with antioxidant and antiproliferative activities.{53319,53320,53321} It scavenges hydroxyl radicals in cell-free assays.{53320} Ascorbyl palmitate (0.01%) reduces the rate of autoxidation of soybean, safflower, sunflower, peanut, and corn oil.{53321} It inhibits increases in epidermal ornithine decarboxylase activity and DNA synthesis induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) in mice in a concentration-dependent manner when applied topically.{53319} Ascorbyl palmitate (0.8 and 4 μmol per 200 μl of acetone, applied topically) reduces the number of tumors per mouse and the percentage of mice with tumors in a mouse skin two-stage model of tumor formation initiated and promoted by 7,12-dimethylbenz[a]anthracene (DMBA) and TPA, respectively. Formulations containing ascorbyl palmitate have been used as antioxidants and preservatives in foods, pharmaceuticals, and cosmetics.  

 

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SKU: 29604 - 500 g Category:

Description

A lipophilic derivative of ascorbic acid with antioxidant and antiproliferative activities; scavenges hydroxyl radicals in cell-free assays; reduces the rate of autoxidation of soybean, safflower, sunflower, peanut, and corn oil at 0.01%; inhibits TPA-induced increases in epidermal ornithine decarboxylase activity and DNA synthesis in mice when applied topically; reduces the number of tumors per mouse and the percentage of mice with tumors in a mouse skin two-stage model of tumor formation initiated and promoted by DMBA and TPA, respectively, at 0.8 and 4 μmol per 200 μl of acetone, applied topically

Formal name: L-ascorbic acid, 6-hexadecanoate

Synonyms:  Ascorbylpalmitic Acid|NSC 402451

Molecular weight: 414.5

CAS: 137-66-6

Purity: ≥98%

Formulation: A solid

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