An essential amino acid; serves as a substrate for TPH

L-Tryptophan – 250 g

Brand:
Cayman
CAS:
73-22-3
Storage:
-20
UN-No:
Non-Hazardous - /

L-Tryptophan is an essential amino acid.{53275} It serves as a substrate for tryptophan hydroxylase (TPH), indoleamine-2,3-dioxygenase (IDO), and tryptophan-2,3-dioxygenase (TDO) for the biosynthesis of serotonin (5-HT; Item No. 14332) and kynurenine (Item No. 11305).{53276} L-Tryptophan is also metabolized by enteric bacteria expressing tryptophanase into indole, pyruvate, and ammonia.{53033} It increases 5-HT, 5-hydroxy-L-tryptophan (5-HTP; Item No. 20539), and 5-hydroxyindolacetic acid (5-HIAA; Item No. 22889) levels in the diencephalon of rats when administered at a dose of 300 mg/kg.{53277} L-Tryptophan decreases the time rats spent immobile in the forced swim test, indicating antidepressant-like activity, when administered at doses of 4 and 20 mg/kg per day for eight weeks.{53278}  

 

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SKU: 29600 - 250 g Category:

Description

An essential amino acid; serves as a substrate for TPH, IDO, and TDO for the biosynthesis of 5-HT and kynurenine; metabolized by enteric bacteria expressing tryptophanase into indole, pyruvate, and ammonia; increases 5-HT, 5-HTP, and 5-HIAA levels in the diencephalon of rats at 300 mg/kg; decreases the time rats spent immobile in the forced swim test, indicating antidepressant-like activity, at 4 and 20 mg/kg per day for eight weeks

Formal name:

Synonyms:  (–)-Tryptophan|NSC 13119

Molecular weight: 204.2

CAS: 73-22-3

Purity: ≥98%

Formulation: A crystalline solid

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