An alkaloid with diverse biological activities; cytotoxic to various cancer cell lines (IC50s = 1.64-12.86 mM); nematocidal against B. xylophilus in vitro; reduces infarct size

Sophocarpine – 10 mg

Brand:
Cayman
CAS:
6483-15-4
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Sophocarpine is an alkaloid that has been found in S. flavescens roots and has diverse biological activities.{39318,46624,46625,46626,46627} It is cytotoxic to HL-60, U937, K562, EC109, A549, and HepG2 cancer cells (IC50s = 1.64-12.86 mM).{39318} Sophocarpine is nematocidal against B. xylophilus in vitro.{46624} In vivo, sophocarpine (30 mg/kg) reduces infarct size, cardiac muscle fiber swelling and hypertrophy, and neutrophil infiltration in a rat model of myocardial ischemia and reperfusion injury.{46625} It decreases liver weight, fibrosis, and levels of IL-6, TNF-α, and TGF-β1 in a rat model of non-alcoholic steatohepatitis (NASH).{46626} Sophocarpine (15 and 30 mg/kg) reduces carrageenan-induced hind paw edema in rats and decreases acetic acid-induced writhing in mice.{46627}  

 

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SKU: 29598 - 10 mg Category:

Description

An alkaloid with diverse biological activities; cytotoxic to various cancer cell lines (IC50s = 1.64-12.86 mM); nematocidal against B. xylophilus in vitro; reduces infarct size, cardiac muscle fiber swelling and hypertrophy, and neutrophil infiltration in a rat model of myocardial ischemia and reperfusion injury at 30 mg/kg; decreases liver weight, fibrosis, and levels of IL-6, TNF-α, and TGF-β1 in a rat model of NASH; reduces carrageenan-induced hind paw edema in rats and decreases acetic acid-induced writhing in mice at 15 and 30 mg/kg

Formal name: (7aS,13aR,13bR,13cS)-2,3,6,7,7a,8,13,13a,13b,13c-decahydro-1H,5H,10H-dipyrido[2,1-f:3′,2′,1′-ij][1,6]naphthyridin-10-one

Synonyms:  13,14-Dehydromatrine

Molecular weight: 246.4

CAS: 6483-15-4

Purity: ≥98%

Formulation: A crystalline solid

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