Description
A second generation sulfonylurea; selectively inhibits IKATP in pancreatic β-cells (IC50s = 0.45, 119.1, and 149.7 µM for HIT-T15 cells, cardiomyocytes, and vascular smooth muscle cells, respectively); PPARγ agonist (EC50 = 10 μM in a transactivation assay); decreases plasma levels of D-glucose and stimulates insulin release in anesthetized rats at 0.2 nmol/g; decreases blood glucose levels, serum ALP, AST, and ALT activities, and hepatic lipid peroxidation and increases hepatic GSH levels in a rat model of STZ-induced at 10 mg/kg
Formal name: N-[(cyclohexylamino)carbonyl]-4-[2-(3,4-dihydro-7-methoxy-4,4-dimethyl-1,3-dioxo-2(1H)-isoquinolinyl)ethyl]-benzenesulfonamide
Synonyms: AR-DF 26
Molecular weight: 527.6
CAS: 33342-05-1
Purity: ≥98%
Formulation: A crystalline solid