An ACE inhibitor; inhibits angiotensin I-induced contraction in isolated rat thoracic aorta (IC50 = 6.9 nM); potentiates bradykinin-induced contraction in isolated guinea pig ileum (AC50 = 2.7 nM); induces relaxation of norepinephrine- or potassium chloride-precontracted isolated rat thoracic aorta with intact endothelium in a concentration-dependent manner; inhibits angiotensin I-induced pressor responses in rats and dogs (ID50s = 9.9 and 7.2 μg/kg

Trandolaprilat (hydrate) – 5 mg

Brand:
Cayman
CAS:
951393-55-8
Storage:
-20
UN-No:
Non-Hazardous - /

Trandolaprilat is an angiotensin-converting enzyme (ACE) inhibitor.{52253} It inhibits angiotensin I-induced contraction in isolated rat thoracic aorta (IC50 = 6.9 nM) and potentiates bradykinin-induced contraction in isolated guinea pig ileum with a 50% augmentation concentration (AC50) value of 2.7 nM. Trandolaprilat induces relaxation of norepinephrine- or potassium chloride-precontracted isolated rat thoracic aorta with intact endothelium in a concentration-dependent manner. Trandolaprilat inhibits angiotensin I-induced pressor responses in rats and dogs (ID50s = 9.9 and 7.2 μg/kg, respectively) and potentiates the bradykinin-induced depressor response in rats (ED50 = 5.5 μg/kg).{52254}  

 

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SKU: 29577 - 5 mg Category:

Description

An ACE inhibitor; inhibits angiotensin I-induced contraction in isolated rat thoracic aorta (IC50 = 6.9 nM); potentiates bradykinin-induced contraction in isolated guinea pig ileum (AC50 = 2.7 nM); induces relaxation of norepinephrine- or potassium chloride-precontracted isolated rat thoracic aorta with intact endothelium in a concentration-dependent manner; inhibits angiotensin I-induced pressor responses in rats and dogs (ID50s = 9.9 and 7.2 μg/kg, respectively); potentiates the bradykinin-induced depressor response in rats (ED50 = 5.5 μg/kg)

Formal name: (2S,3aR,7aS)-1-[(2S)-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]-1-oxopropyl]octahydro-1H-Indole-2-carboxylic acid, monohydrate

Synonyms:  RU 44403

Molecular weight: 420.5

CAS: 951393-55-8

Purity: ≥95%

Formulation: A solid

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