A fungal metabolite with diverse biological activities; inhibits C. histolyticum collagenase but not elastase or trypsin in cell-free assays (IC50s = 0.37

Aranciamycin – 1 mg

Brand:
Cayman
CAS:
72389-06-1
Storage:
-20
UN-No:
De Minimis - 3462 / 6.1

Aranciamycin is a fungal metabolite that has been found in Streptomyces and has diverse biological activities.{52436,52437} It inhibits C. histolyticum collagenase but not elastase or trypsin in cell-free assays (IC50s = 0.37, >10, and >10 µM, respectively).{52436} Aranciamycin is active against M. bovis and B. subtilis (MICs = 30 and 15 µM, respectively).{52437} It is cytotoxic to HepG2 cells (IC50 = 18 µM).  

 

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SKU: 29575 - 1 mg Category:

Description

A fungal metabolite with diverse biological activities; inhibits C. histolyticum collagenase but not elastase or trypsin in cell-free assays (IC50s = 0.37, >10, and >10 µM, respectively); active against M. bovis and B. subtilis (MICs = 30 and 15 µM, respectively); cytotoxic to HepG2 cells (IC50 = 18 µM)

Formal name: (2S,3S,4R)-4-[(6-deoxy-2-O-methyl-α-L-mannopyranosyl)oxy]-3,4-dihydro-2,5,7-trihydroxy-3-methoxy-2-methyl-1,6,11(2H)-naphthacenetrione

Synonyms:  NSC 369226

Molecular weight: 544.5

CAS: 72389-06-1

Purity: ≥70%

Formulation: A solid

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