A Pim kinase inhibitor (Kis = 5

TP-3654 – 5 mg

Brand:
Cayman
CAS:
1361951-15-6
Storage:
-20
UN-No:
Non-Hazardous - /

TP-3654 is an inhibitor of Pim kinases (Kis = 5, 239, and 42 nM for Pim-1, Pim-2, and Pim-3, respectively).{45703} It inhibits 19 additional kinases, including PI3Kα, PI3Kγ, and PI3Kδ, with IC50 values of less than 300 nM. TP-3654 inhibits phosphorylation of Bad in HEK293 cells overexpressing Bad and Pim-1 (EC50 = 67 nM), as well as in UM-UC-3 cells. It reduces tumor growth in UM-UC-3 bladder carcinoma and PC3 prostate adenocarcinoma mouse xenograft models when administered at a dose of 200 mg/kg.  

 

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SKU: 29571 - 5 mg Category:

Description

A Pim kinase inhibitor (Kis = 5, 239, and 42 nM for Pim-1, Pim-2, and Pim-3, respectively); inhibits 19 additional kinases, including PI3Kα, PI3Kγ, and PI3Kδ, with IC50 values 50 = 67 nM), as well as in UM-UC-3 cells; reduces tumor growth in UM-UC-3 bladder carcinoma and PC3 prostate adenocarcinoma mouse xenograft models at 200 mg/kg

Formal name: trans-α,α-dimethyl-4-[[3-[3-(trifluoromethyl)phenyl]imidazo[1,2-b]pyridazin-6-yl]amino]-cyclohexanemethanol

Synonyms: 

Molecular weight: 418.5

CAS: 1361951-15-6

Purity: ≥98%

Formulation: A crystalline solid

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