An azadirachtin with diverse biological activities; has antifeedant activity against P. xylostella third instar larvae at 3 mg/ml induces mortality (LC50 = 1.03 mg/ml); induces mortality in M. incognita second instar larvae (LD50 = 125.8 ppm); reduces the number of papillomas formed on mouse skin in a model of skin carcinogenesis induced by peroxynitrite and TPA at 780 nmol in the drinking water but is not cytotoxic to HL-60

Azadirachtin B – 1 mg

Brand:
Cayman
CAS:
106500-25-8
Storage:
-20
UN-No:
Non-Hazardous - /

Azadirachtin B is an azadirachtin that has been found in the neem tree, A. indica, and has diverse biological activities, including insecticidal, nematocidal, anticancer, and osteogenic properties.{46667,46668,46669,46670,46671} It has antifeedant activity against P. xylostella third instar larvae when used at a concentration of 3 mg/ml and induces mortality with an LC50 of 1.03 mg/ml.{46668} It induces mortality in M. incognita second instar larvae with an LD50 value of 125.8 ppm.{46669} Azadirachtin B (780 nmol in the drinking water) reduces the number of papillomas formed on mouse skin in a model of skin carcinogenesis induced by peroxynitrite and phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) but is not cytotoxic to HL-60, A549, AZ521, SK-BR-3, or CRL1579 cancer cells (IC50s = >20 µM for all).{46670,46671} It induces osteoblast differentiation and increases the rate of osteoblast proliferation in primary calvarial osteoblast cells when used at concentrations of 100 pM and 10 nM but not 1 pM, 1 µM, or 100 µM.{46667}  

 

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SKU: 29569 - 1 mg Category:

Description

An azadirachtin with diverse biological activities; has antifeedant activity against P. xylostella third instar larvae at 3 mg/ml induces mortality (LC50 = 1.03 mg/ml); induces mortality in M. incognita second instar larvae (LD50 = 125.8 ppm); reduces the number of papillomas formed on mouse skin in a model of skin carcinogenesis induced by peroxynitrite and TPA at 780 nmol in the drinking water but is not cytotoxic to HL-60, A549, AZ521, SK-BR-3, or CRL1579 cancer cells (IC50s = >20 µM for all); It induces osteoblast differentiation and increases the rate of osteoblast proliferation in primary calvarial osteoblast cells at 100 pM and 10 nM but not 1 pM, 1 µM, or 100 µM

Formal name: (2aR,3S,4S,4aR,5S,7aS,8S,10R,10aS,10bR)-octahydro-3,8-dihydroxy-4-methyl-10-[[(2E)-2-methyl-1-oxo-2-buten-1-yl]oxy]-4-[(1aR,2S,3aS,6aS,7S,7aS)-3a,6a,7,7a-tetrahydro-6a-hydroxy-7a-methyl-2,7-methanofuro[2,3-b]oxireno[e]oxepin-1a(2H)-yl]-7H,8H-furo[3′,4′:4,4a]naphtho[1,8-bc]furan-5,10a(1H)-dicarboxylic acid, 5,10a-dimethyl ester

Synonyms:  3-Tigloylazadirachtol|Deacetylazadirachtinol

Molecular weight: 662.7

CAS: 106500-25-8

Purity: ≥95%

Formulation: A solid

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