Description
The C-15 epimer of PGF1α
Formal name: 9α,11α,15R-trihydroxy-prost-13E-en-1-oic acid
Synonyms: 15(R)-PGF1α|15-epi PGF1α
Molecular weight: 356.5
CAS: 21562-54-9
Purity: ≥95%
Formulation: A solution in methyl acetate
15(R)-Prostaglandin F1α – 500 µg
Brand:
Cayman
CAS:
21562-54-9
Storage:
-20
UN-No:
Excepted Quantity - 1231 / 3
Available on backorder
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The tetracycline repressor (TetR) is a transcriptional regulator which normally binds tightly to its palindromic tetO operator DNA, blocking gene expression.{17508} Tet causes the repressor to dissociate from the DNA, allowing transcription to occur. A novel reverse TetR (revTetR) requires tetracycline as a co-repressor to bind tetO and block transcription.{17509,17510} Anhydrotetracycline (hydrochloride) is a powerful effector in both the tetracycline repressor (TetR) and reverse TetR (revTetR) systems, binding the Tet repressor 35-fold more strongly than Tet.{17508,17511} Moreover, anhydrotetracycline poorly binds the 30S ribosomal subunit, compared to Tet,{17512} so it does not act as a general inhibitor of translation and is a poor antibiotic. Perhaps related to this, the concentration of anhydrotetracycline that inhibits eukaryotic cell growth is more than a 1,000-fold above the dose that alters transcription through TetR.{17508}
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