A metabolite of DCA; fecal levels are elevated in rats fed a diet supplemented with cholic acid or DCA compared with rats fed a control diet or a diet supplemented with cholesterol

12-keto Lithocholic Acid – 10 mg

Brand:
Cayman
CAS:
5130-29-0
Storage:
-20
UN-No:
Non-Hazardous - /

12-keto Lithocholic acid is a metabolite of the secondary bile acid deoxycholic acid (DCA; Item Nos. 20756 | 18231).{46886,46887} Fecal levels of 12-keto lithocholic acid are elevated in rats fed a diet supplemented with cholic acid (Item No. 20250) or DCA compared with rats fed a control diet or a diet supplemented with cholesterol (Item No. 9003100), hyodeoxycholic acid (HDCA; Item No. 20294), or lithocholic acid (LCA; Item No. 20253).{46887} 12-keto Lithocholic acid activates the human pregnane X receptor (PXR; EC50 = 31.3 μM in a cell-based transactivation assay).{46888} 12-keto Lithocholic acid levels are increased in duodenal bile from patients with type 2 diabetes.{46889}  

 

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Description

A metabolite of DCA; fecal levels are elevated in rats fed a diet supplemented with cholic acid or DCA compared with rats fed a control diet or a diet supplemented with cholesterol, HDCA, or LCA; activates the human PXR (EC50 = 31.3 μM in a cell-based transactivation assay); levels are increased in duodenal bile from patients with type 2 diabetes

Formal name: (3α,5β)-3-hydroxy-12-oxo-cholan-24-oic acid

Synonyms:  12-keto-LCA|12-Oxolithocholic Acid

Molecular weight: 390.6

CAS: 5130-29-0

Purity: ≥98%

Formulation: A solid

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