Description
A PDE4 inhibitor (IC50 = 2.2 nM for the human peripheral leukocyte enzyme); selective for PDE4 over PDE1, -2, -3, and -5 (IC50s = >3 µM for all); inhibits LPS-induced TNF-α production in human PBMCs; inhibits carrageenan-induced pleural cavity cell infiltration in a rat model of pleurisy (ED30 = 9.1 mg/kg); inhibits antigen-induced lung eosinophil infiltration in rats, mice, and ferrets (ED50s = 1.7, 5.8, and 1.2 mg/kg, respectively); does not induce emesis in ferrets at doses up to 10 mg/kg; reduces ovalbumin-induced bronchoconstriction, as well as airway plasma leakage, eosinophil infiltration, and hyperreactivity in a guinea pig model of asthma (ED50s = 7.3, 5.7, 1, and 0.52 mg/kg, respectively); reduces citric acid-induced cough in guinea pigs
Formal name: 4-(3-chlorophenyl)-1,7-diethyl-pyrido[2,3-d]pyrimidin-2(1H)-one
Synonyms:
Molecular weight: 313.8
CAS: 191219-80-4
Purity: ≥98%
Formulation: A solid
