An atypical antipsychotic; dopamine D2 receptor partial agonist and an agonist of the serotonin (5-HT) receptor subtype 5-HT1A (Kis = 2.2 and 9.3 nM

Bifeprunox (mesylate) – 5 mg

Brand:
Cayman
CAS:
350992-13-1
Storage:
-20
UN-No:
Non-Hazardous - /

Bifeprunox is an atypical antipsychotic.{52217} It is a dopamine D2 receptor partial agonist and an agonist of the serotonin (5-HT) receptor subtype 5-HT1A (Kis = 2.2 and 9.3 nM, respectively).{52219,52218} Bifeprunox inhibits apomorphine-induced climbing behavior in mice (ED50 = 0.1 mg/kg) and the conditioned avoidance response in rats (ED50 = 0.8 mg/kg).{52218} It decreases basal prepulse inhibition of the acoustic startle response in rats by 42% when administered at a dose of 10 mg/kg.{52219}  

 

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SKU: 29523 - 5 mg Category:

Description

An atypical antipsychotic; dopamine D2 receptor partial agonist and an agonist of the serotonin (5-HT) receptor subtype 5-HT1A (Kis = 2.2 and 9.3 nM, respectively); inhibits apomorphine-induced climbing behavior in mice (ED50 = 0.1 mg/kg) and the conditioned avoidance response in rats (ED50 = 0.8 mg/kg); decreases basal prepulse inhibition of the acoustic startle response in rats by 42% at 10 mg/kg

Formal name: 7-[4-([1,1′-biphenyl]-3-ylmethyl)-1-piperazinyl]-2(3H)-benzoxazolone, monomethanesulfonate

Synonyms:  DU 127090

Molecular weight: 481.6

CAS: 350992-13-1

Purity: ≥98%

Formulation: A crystalline solid

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