A histamine H3 receptor agonist (KI = 0.4 nM in SK-N-MC cell membranes expressing the human receptor); selective for histamine H3 over H1 and H2 receptors in CHO cell membranes expressing the guinea pig and human receptors

Immepip (hydrobromide) – 10 mg

Brand:
Cayman
CAS:
164391-47-3
Storage:
-20
UN-No:
Non-Hazardous - /

Immepip is a histamine H3 receptor agonist (KI = 0.4 nM in SK-N-MC cell membranes expressing the human receptor).{52174} It is selective for histamine H3 over H1 and H2 receptors in CHO cell membranes expressing the guinea pig and human receptors, respectively (Kis = >16 μM for both) but also agonizes H4 receptors (KI = 9 nM in SK-N-MC cell membranes expressing the human receptor).{52204,52174} Immepip (5 mg/kg, s.c.) decreases hypothalamic histamine release in anesthetized rats.{52205} It decreases flinching in the formalin test in rats when administered at doses of 5 and 30 mg/kg and inhibits formalin-induced paw edema at 30 mg/kg.{52206}  

 

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SKU: 29518 - 10 mg Category:

Description

A histamine H3 receptor agonist (KI = 0.4 nM in SK-N-MC cell membranes expressing the human receptor); selective for histamine H3 over H1 and H2 receptors in CHO cell membranes expressing the guinea pig and human receptors, respectively (Kis = >16 μM for both) but also agonizes H4 receptors (KI = 9 nM in SK-N-MC cell membranes expressing the human receptor); decreases hypothalamic histamine release in anesthetized rats at 5 mg/kg; decreases flinching in the formalin test in rats at 5 and 30 mg/kg and inhibits formalin-induced paw edema at 30 mg/kg

Formal name: 4-(1H-imidazol-5-ylmethyl)-piperidine, dihydrobromide

Synonyms: 

Molecular weight: 327.1

CAS: 164391-47-3

Purity: ≥95%

Formulation: A crystalline solid

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