A histamine H3 and H4 receptor agonist (Kis = 0.3 and 2.7 nM

Imetit (hydrobromide) – 10 mg

Brand:
Cayman
CAS:
32385-58-3
Storage:
-20
UN-No:
Non-Hazardous - /

Imetit is a histamine H3 and H4 receptor agonist (Kis = 0.3 and 2.7 nM, respectively, in radioligand binding assays).{52174} It is selective for histamine H3 and H4 receptors over H1 and H2 receptors at concentrations up to 100 µM, as well as the serotonin (5-HT) receptor subtype 5-HT3 (Ki = 240 nM).{52175},{52176} Imetit reduces potassium-induced increases in histamine levels in isolated rat cerebral cortex slices (EC50 = 2.8 nM).{52177} It increases scratching in mice (ED50 = 0.9 µmol), an effect that is reduced by the H3 receptor antagonist thioperamide (Item No. 10011127).{52178}  

 

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SKU: 29517 - 10 mg Category:

Description

A histamine H3 and H4 receptor agonist (Kis = 0.3 and 2.7 nM, respectively, in radioligand binding assays); selective for histamine H3 and H4 receptors over H1 and H2 receptors when used at 100 µM, as well as 5-HT3 (Ki = 240 nM); reduces potassium-induced increases in histamine levels in isolated rat cerebral cortex slices (EC50 = 2.8 nM); increases scratching in mice (ED50 = 0.9 µmol)

Formal name: carbamimidothioic acid, 2-(1H-imidazol-5-yl)ethyl ester, dihydrobromide

Synonyms:  VUF 8325

Molecular weight: 332.1

CAS: 32385-58-3

Purity: ≥98%

Formulation: A solid

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