Description
A dopamine D3 receptor agonist; selectively binds to the dopamine D3 over the D2, D1, and D4 receptors (Kis = 0.78, 61, 650, and 5,300 nM, respectively, in radioligand binding assays); increases calcium mobilization in HEK293 cells expressing the D3 receptor (EC50 = 13.5 nM in a FLIPR assay); decreases the release of striatal dopamine and DOPAC in rats at 0.25 mg/kg, i.p.; reduces the loss of ipsilateral SNC dopaminergic neurons in a rat model of 6-OHDA-induced Parkinson’s disease at 2 µg/µl for eight weeks, i.c.v.; decreases amphetamine-induced ipsilateral rotations and increases the number of steps reached with the contralateral paw in the staircase test in the same model
Formal name: 7-(dipropylamino)-5,6,7,8-tetrahydro-2-naphthalenol, monohydrobromide
Synonyms:
Molecular weight: 328.3
CAS: 76135-30-3
Purity: ≥95%
Formulation: A crystalline solid
