A dopamine D3 receptor agonist; selectively binds to the dopamine D3 over the D2

7-hydroxy DPAT (hydrobromide) – 10 mg

Brand:
Cayman
CAS:
76135-30-3
Storage:
-20
UN-No:
Non-Hazardous - /

7-hydroxy DPAT is a dopamine D3 receptor agonist.{52357} It selectively binds to the dopamine D3 over the D2, D1, and D4 receptors (Kis = 0.78, 61, 650, and 5,300 nM, respectively, in radioligand binding assays). 7-hydroxy DPAT increases calcium mobilization in HEK293 cells expressing the D3 receptor with an EC50 value of 13.5 nM in a FLIPR assay.{52358} It decreases the release of striatal dopamine and its metabolite 3,4-dihydroxyphenylacetic acid (DOPAC; Item No. 24912) in rats when administered intraperitoneally at a dose of 0.25 mg/kg.{52359} 7-hydroxy DPAT (2 µg/µl for eight weeks, i.c.v.) reduces the loss of ipsilateral substantia nigra pars compacta (SNC) dopaminergic neurons in a rat model of Parkinson’s disease induced by 6-OHDA (Item No. 25330).{52360} It also decreases amphetamine-induced ipsilateral rotations and increases the number of steps reached with the contralateral paw in the staircase test in the same model.  

 

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Description

A dopamine D3 receptor agonist; selectively binds to the dopamine D3 over the D2, D1, and D4 receptors (Kis = 0.78, 61, 650, and 5,300 nM, respectively, in radioligand binding assays); increases calcium mobilization in HEK293 cells expressing the D3 receptor (EC50 = 13.5 nM in a FLIPR assay); decreases the release of striatal dopamine and DOPAC in rats at 0.25 mg/kg, i.p.; reduces the loss of ipsilateral SNC dopaminergic neurons in a rat model of 6-OHDA-induced Parkinson’s disease at 2 µg/µl for eight weeks, i.c.v.; decreases amphetamine-induced ipsilateral rotations and increases the number of steps reached with the contralateral paw in the staircase test in the same model

Formal name: 7-(dipropylamino)-5,6,7,8-tetrahydro-2-naphthalenol, monohydrobromide

Synonyms: 

Molecular weight: 328.3

CAS: 76135-30-3

Purity: ≥95%

Formulation: A crystalline solid

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