An NNRTI (mean IC50 = 118 nM for the wild-type HIV-1 enzyme); inhibits mutant HIV-1 RTs with mean IC50 values within 10-fold of the wild-type enzyme; inhibits HIV-1 virus replication in MT-2 cells (EC50s = 5.04

Lersivirine – 5 mg

Brand:
Cayman
CAS:
473921-12-9
Storage:
-20
UN-No:
Non-Hazardous - /

Lersivirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI; mean IC50 = 118 nM for the wild-type HIV-1 enzyme).{57297} It inhibits a panel of 14 single-point mutant HIV-1 reverse transcriptases with mean IC50 values within 10-fold of the wild-type enzyme. Lersivirine inhibits HIV-1 virus replication in MT-2 cells with EC50 values of 5.04, 13.1, and 34.9 nM at multiplicities of infection (MOIs) of 0.005, 0.05, and 0.5, respectively, and exhibits synergistic or additive effects when used in combination with a variety of antiretroviral agents.  

 

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SKU: 29497 - 5 mg Category:

Description

An NNRTI (mean IC50 = 118 nM for the wild-type HIV-1 enzyme); inhibits mutant HIV-1 RTs with mean IC50 values within 10-fold of the wild-type enzyme; inhibits HIV-1 virus replication in MT-2 cells (EC50s = 5.04, 13.1, and 34.9 nM at MOIs of 0.005, 0.05, and 0.5, respectively); exhibits synergistic or additive effects when used in combination with a variety of antiretroviral agents

Formal name: 5-[[3,5-diethyl-1-(2-hydroxyethyl)-1H-pyrazol-4-yl]oxy]-1,3-benzenedicarbonitrile

Synonyms:  UK-453,061

Molecular weight: 310.4

CAS: 473921-12-9

Purity: ≥98%

Formulation: A crystalline solid

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