An AT2 receptor antagonist (IC50 = 1.2 nM in rat adrenal gland membranes); binds to the AT1 receptor (Ki = 46.6 nM in rat liver epithelial cells); reduces the AT2-induced pressor response in rats; decreases mean arterial pressure in a rat model of hypertension induced by renal artery constriction at 1 and 3 mg/kg intragastrically or intravenously

Tasosartan – 250 mg

Brand:
Cayman
CAS:
145733-36-4
Storage:
-20
UN-No:
Non-Hazardous - /

Tasosartan is an angiotensin II type 2 (AT2) receptor antagonist (IC50 = 1.2 nM in rat adrenal gland membranes).{48831} It also binds to the AT1 receptor (Ki = 46.6 nM in rat liver epithelial cells).{48832} Tasosartan (3 mg/kg, intraduodenally) reduces the AT2-induced pressor response in rats.{48833} It also decreases mean arterial pressure in a rat model of hypertension induced by renal artery constriction when administered intragastrically or intravenously at doses of 1 and 3 mg/kg.{48831}  

 

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SKU: 29495 - 250 mg Category:

Description

An AT2 receptor antagonist (IC50 = 1.2 nM in rat adrenal gland membranes); binds to the AT1 receptor (Ki = 46.6 nM in rat liver epithelial cells); reduces the AT2-induced pressor response in rats; decreases mean arterial pressure in a rat model of hypertension induced by renal artery constriction at 1 and 3 mg/kg intragastrically or intravenously

Formal name: 5,8-dihydro-2,4-dimethyl-8-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-pyrido[2,3-d]pyrimidin-7(6H)-one

Synonyms:  WAY-ANA-756

Molecular weight: 411.5

CAS: 145733-36-4

Purity: ≥98%

Formulation: A crystalline solid

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