An inhibitor of dynamin (IC50s = 380 and 2

Dyngo-4a – 50 mg

Brand:
Cayman
CAS:
1256493-34-1
Storage:
-20
UN-No:
Non-Hazardous - /

Dyngo-4a is an inhibitor of dynamin with IC50 values of 380 and 2,300 nM for native sheep brain dynamin 1 and recombinant rat dynamin 2, respectively.{46647} It inhibits dynamin 1 helix formation induced by L-phosphatidylserine (PS) liposomes (IC50 = 0.38 µM) more potently than dynamin 1 single-ring formation induced by Grb2 (IC50 = 39.2 µM) and does not inhibit the basal GTPase activity of dynamin.{46647,46648} Dyngo-4a inhibits non-neuronal clathrin-mediated (IC50 = 5.7 µM in U2OS cells) and synaptic vesicle endocytosis (IC50 = 26.8 µM in rat brain synaptosomes).{46647}  

 

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SKU: 29479 - 50 mg Category:

Description

An inhibitor of dynamin (IC50s = 380 and 2,300 nM for native sheep brain dynamin 1 and recombinant rat dynamin 2, respectively); inhibits PS liposome-induced dynamin 1 helix formation (IC50 = 0.38 µM) more potently than Grb2-induced single-ring dynamin 1 formation (IC50 = 39.2 µM); does not inhibit the basal GTPase activity of dynamin; inhibits non-neuronal clathrin-mediated (IC50 = 5.7 µM in U2OS cells) and synaptic vesicle endocytosis (IC50 = 26.8 µM in rat brain synaptosomes)

Formal name: 3-hydroxy-2-naphthalenecarboxylic acid, 2-[(2,4,5-trihydroxyphenyl)methylene]hydrazide

Synonyms: 

Molecular weight: 338.3

CAS: 1256493-34-1

Purity: ≥95%

Formulation: A crystalline solid

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