![A positive allosteric modulator of mGluR8; potentiates glutamate-induced [35S]GTPγS binding in GHEK cells expressing human mGluR8b (EC50 = 1 μM); inhibits MPP+-induced decreases in the viability of undifferentiated SH-SY5Y cells at 0.001-1 μM and in retinoic acid-differentiated SH-SY5Y cells at 0.1 and 1 μM; increases the time spent in the open areas of the elevated zero maze and reduces the acoustic startle response](https://interpriseusa.com/wp-content/uploads/2021/06/29460.png)
Description
A positive allosteric modulator of mGluR8; potentiates glutamate-induced [35S]GTPγS binding in GHEK cells expressing human mGluR8b (EC50 = 1 μM); inhibits MPP+-induced decreases in the viability of undifferentiated SH-SY5Y cells at 0.001-1 μM and in retinoic acid-differentiated SH-SY5Y cells at 0.1 and 1 μM; increases the time spent in the open areas of the elevated zero maze and reduces the acoustic startle response, avoidable and unavoidable anxiogenic stimuli, respectively, in mice at 10 mg/kg
Formal name: 2-[[(4-bromophenyl)methyl]thio]-N-[4-(1-methylpropyl)phenyl]-acetamide
Synonyms:
Molecular weight: 392.4
CAS: 1290628-31-7
Purity: ≥98%
Formulation: A crystalline solid
