Description
A TLR7 agonist (EC50 = 50.1 nM in a reporter assay using HEK293 cells expressing the human receptor); selective for TLR7 over TLR8 (EC50 = >10 µM); induces IFN production in isolated human PBMCs (MEC = 10 nM); induces proliferation of isolated mouse, rat, and dog splenocytes (EC50s = 3.98, 6.31, and 12.59 nM, respectively); inhibits BALF eosinophil infiltration in a rat model of ovalbumin-sensitized and -challenged allergic airway inflammation,,
Formal name: 3-[(6-amino-2-butoxy-7,8-dihydro-8-oxo-9H-purin-9-yl)methyl]-benzeneacetic acid, methyl ester
Synonyms:
Molecular weight: 385.4
CAS: 677773-91-0
Purity: ≥95%
Formulation: A crystalline solid
