A fungal metabolite; a weak ACAT inhibitor (IC50 = 145 µM); active against the bacteria B. cereus and B. subtilis (MICs = 100 µg/ml for both) but not S. aureus

Terpendole I – 1 mg

Brand:
Cayman
CAS:
167612-17-1
Storage:
-20
UN-No:
Non-Hazardous - /

Terpendole I is a fungal metabolite that has been found in A. yamanashiensis.{45646} It is a weak inhibitor of acyl-coenzyme A:cholesterol acyltransferase (ACAT; IC50 = 145 µM) and is active against the bacteria B. cereus and B. subtilis (MICs = 100 µg/ml for both) but not S. aureus, P. aeruginosa, or K. pneumoniae (MICs = >200 µg/ml for all) or the fungus C. albicans (MIC = 200 µg/ml).{45646,45647} It is cytotoxic to HeLa cells with an IC50 value of 52.6 µM.{45648}  

 

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SKU: 29443 - 1 mg Category:

Description

A fungal metabolite; a weak ACAT inhibitor (IC50 = 145 µM); active against the bacteria B. cereus and B. subtilis (MICs = 100 µg/ml for both) but not S. aureus, P. aeruginosa, or K. pneumoniae (MICs = >200 µg/ml for all) or the fungus C. albicans (MIC = >200 µg/ml); cytotoxic to HeLa cells (IC50 = 52.6 µM)

Formal name: (2S,3R,3aR,4aS,4bS,6aS,12bS,12cR,14aS)-3,3a,5,6,6a,7,12,12b,12c,13,14,14a-dodecahydro-2-(1-hydroxy-1-methylethyl)-12b,12c-dimethyl-2H,4bH-oxireno[4′,4′a]-1-benzopyrano[5′,6′:6,7]indeno[1,2-b]indole-3,4b-diol

Synonyms: 

Molecular weight: 453.6

CAS: 167612-17-1

Purity: ≥95%

Formulation: A solid

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