A broad-spectrum MMP inhibitor (IC50s = 0.7

CP 471,474 – 1 mg

Brand:
Cayman
CAS:
210755-45-6
Storage:
-20
UN-No:
Non-Hazardous - /

CP 471,474 is a broad-spectrum inhibitor of matrix metalloproteinases (MMPs) with IC50 values of 0.7, 16, 13, and 0.9 nM for MMP-2, MMP-3, MMP-9, and MMP-13, respectively.{52163} It is selective for these MMPs over MMP-1 (IC50 = 1,170 nM). CP 471,474 reduces left ventricular enlargement and decreases the incidence of cardiac rupture in mouse models of myocardial infarction when administered at doses of 120 mg/kg twice per day and 240 mg/kg per day, respectively.{52163,52164}  

 

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SKU: 29442 - 1 mg Category:

Description

A broad-spectrum MMP inhibitor (IC50s = 0.7, 16, 13, and 0.9 nM for MMP-2, MMP-3, MMP-9, and MMP-13, respectively); selective for these MMPs over MMP-1 (IC50 = 1,170 nM); reduces left ventricular enlargement and decreases the incidence of cardiac rupture in mouse models of myocardial infarction at 120 mg/kg twice per day and 240 mg/kg per day, respectively

Formal name: 2-[[[4-(4-fluorophenoxy)phenyl]sulfonyl]amino]-N-hydroxy-2-methyl-propanamide

Synonyms: 

Molecular weight: 368.4

CAS: 210755-45-6

Purity: ≥98%

Formulation: A crystalline solid

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