A xanthine derivative and neuroprotective agent; increases NGF production in primary mouse astroglia maximally at 1.11 mM; reduces Aβ42-induced cell death in primary rat hippocampal neurons at 20 µg/ml; reduces infarct volume in a rat model of ischemic brain damage induced by permanent MCAO when administered following MCAO as an i.v. infusion at 0.01

Propentofylline – 5 mg

Brand:
Cayman
CAS:
55242-55-2
Storage:
-20
UN-No:
Non-Hazardous - /

Propentofylline is a xanthine derivative and neuroprotective agent.{53286,53287} It increases NGF production in primary mouse astroglia when used at concentrations ranging from 0.12 to 3.33 mM, with the maximum increase observed at 1.11 mM.{53286} Propentofylline (20 µg/ml) reduces cell death induced by amyloid-β (1-42) (Aβ42; Item No. 20574) in primary rat hippocampal neurons.{53287} Intravenous infusion of propentofylline (0.01, 0.05, and 0.1 mg/kg per minute) reduces infarct volume in a rat model of ischemic brain damage induced by permanent middle cerebral artery occlusion (MCAO) when administered following MCAO.{53288} It inhibits cAMP phosphodiesterases, is an antagonist of adenosine A1 and A2 receptors, and binds to adenosine transporters.{53289,53290}  

 

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SKU: 29431 - 5 mg Category:

Description

A xanthine derivative and neuroprotective agent; increases NGF production in primary mouse astroglia maximally at 1.11 mM; reduces Aβ42-induced cell death in primary rat hippocampal neurons at 20 µg/ml; reduces infarct volume in a rat model of ischemic brain damage induced by permanent MCAO when administered following MCAO as an i.v. infusion at 0.01, 0.05, and 0.1 mg/kg per minute; inhibits cAMP phosphodiesterases, is an antagonist of adenosine A1 and A2 receptors, and binds to adenosine transporters

Formal name: 3,7-dihydro-3-methyl-1-(5-oxohexyl)-7-propyl-1H-purine-2,6-dione

Synonyms:  HOE 285|HWA 285

Molecular weight: 306.4

CAS: 55242-55-2

Purity: ≥98%

Formulation: A solid

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