An activator of IKCa1/KCa3.1 channels; activates IKCa1/KCa3.1 and induces chloride secretion in T84 monolayers in a concentration-dependent manner; potentiates the activity of SK channels (EC50 = 27 µM in HEK293 cells expressing recombinant human SK2 channels); potentiates SK channel-mediated IAHP in CA1 pyramidal neurons at 100 µM; induces chloride secretion in isolated mouse jejunum (EC50 = 41 µM)

DCEBIO – 50 mg

Brand:
Cayman
CAS:
60563-36-2
Storage:
-20
UN-No:
Non-Hazardous - /

DCEBIO is an activator of intermediate conductance calcium-activated potassium (IKCa1/KCa3.1) channels and a dichlorinated derivative of the KCa channel activator 1-EBIO (Item No. 14575).{48824} It activates IKCa1/KCa3.1 and induces chloride secretion in T84 monolayers in a concentration-dependent manner, an effect that can be blocked by the IKCa1 inhibitor charybdotoxin (Item No. 24115). DCEBIO potentiates the activity of small conductance calcium-activated potassium (SK) channels with an EC50 value of 27 µM in HEK293 cells expressing recombinant human SK2 channels by increasing the apparent calcium sensitivity of the channel.{48825} It also potentiates SK channel-mediated apamin-sensitive after-hyperpolarizing currents (IAHP) in CA1 pyramidal neurons, increasing the amplitude and duration of IAHP when used at a concentration of 100 µM. DCEBIO induces chloride secretion in isolated mouse jejunum (EC50 = 41 µM), an effect that is reduced by the cystic fibrosis transmembrane conductance regulator (CFTR) inhibitors glibenclamide and NPPB.{48826}  

 

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SKU: 29426 - 50 mg Category:

Description

An activator of IKCa1/KCa3.1 channels; activates IKCa1/KCa3.1 and induces chloride secretion in T84 monolayers in a concentration-dependent manner; potentiates the activity of SK channels (EC50 = 27 µM in HEK293 cells expressing recombinant human SK2 channels); potentiates SK channel-mediated IAHP in CA1 pyramidal neurons at 100 µM; induces chloride secretion in isolated mouse jejunum (EC50 = 41 µM)

Formal name: 5,6-dichloro-1-ethyl-1,3-dihydro-2H-benzimidazol-2-one

Synonyms: 

Molecular weight: 231.1

CAS: 60563-36-2

Purity: ≥98%

Formulation: A solid

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