A stearoyl-CoA desaturase inhibitor (IC50s = 3

MK-8245 – 5 mg

Brand:
Cayman
CAS:
1030612-90-8
Storage:
-20
UN-No:
Non-Hazardous - /

MK-8245 is a liver-targeted inhibitor of stearoyl-CoA desaturase (SCD; IC50s = 3, 3, and 1 nM for rat, mouse, and human SCD1, respectively).{53163} It is selective for SCD1 over Δ5- and Δ6-desaturases (IC50s = >100,000 nM). MK-8245 (20-60 mg/kg) reduces the hepatic, but not Harderian gland, ratio of oleic acid to stearic acid, a marker of chronic SCD activity, and blood glucose levels, without inducing the formation of skin lesions or eye squinting behavior, in a mouse model of high-fat diet-induced obesity. It also inhibits hepatitis C virus (HCV) replication without inducing cytotoxicity in LucNeo2 cells (IC50 = 39.8 nM).{53164}  

 

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SKU: 29421 - 5 mg Category:

Description

A stearoyl-CoA desaturase inhibitor (IC50s = 3, 3, and 1 nM for rat , mouse, and human SCD1, respectively); selective for SCD1 over Δ5- and Δ6-desaturases (IC50s = >100,000 nM); reduces the hepatic, but not Harderian gland, ratio of oleic acid to stearic acid and blood glucose levels in a mouse model of high-fat diet-induced obesity from 20-60 mg/kg; inhibits HCV replication in LucNeo2 cells (IC50 = 39.8 nM)

Formal name: 5-[3-[4-(2-bromo-5-fluorophenoxy)-1-piperidinyl]-5-isoxazolyl]-2H-tetrazole-2-acetic acid

Synonyms: 

Molecular weight: 467.3

CAS: 1030612-90-8

Purity: ≥98%

Formulation: A crystalline solid

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