A histamine H2 receptor agonist (Ki = 44 µM in guinea pig right atrium); selectively stimulates H2 over H1 and H3 receptors with relative potencies of 71

Dimaprit (hydrochloride) – 250 mg

Brand:
Cayman
CAS:
23256-33-9
Storage:
-20
UN-No:
Non-Hazardous - /

Dimaprit is a histamine H2 receptor agonist with a Ki value of 44 µM in guinea pig right atrium.{46616,46612} It is selective for histamine H2 over H1 and H3 receptors with relative potencies of 71, A. suum extract, which is not affected by pretreatment with mepyramine (Item No. 20978), an H1 receptor inverse agonist, or cimetidine (Item No. 18743), an H2 receptor antagonist.{46613} It stimulates gastric acid secretion in vivo in anaesthetized rats and cats with relative potencies of 19.5 and approximately 400 to 500, respectively, compared to histamine.{46614} Dimaprit inhibits 2-(2-pyridyl)ethylamine-induced bronchoconstriction in guinea pigs in a dose-dependent manner.{46615}  

 

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SKU: 29418 - 250 mg Category:

Description

A histamine H2 receptor agonist (Ki = 44 µM in guinea pig right atrium); selectively stimulates H2 over H1 and H3 receptors with relative potencies of 71, A. suum extract, which is not affected by pretreatment with mepyramine or cimetidine; stimulates gastric acid secretion in vivo in anaesthetized rats and cats with relative potencies of 19.5 and approximately 400 to 500, respectively, compared to histamine; inhibits 2-(2-pyridyl)ethylamine-induced bronchoconstriction in guinea pigs in a dose-dependent manner

Formal name: carbamimidothioic acid, 3-(dimethylamino)propyl ester, dihydrochloride

Synonyms: 

Molecular weight: 234.2

CAS: 23256-33-9

Purity: ≥95%

Formulation: A crystalline solid

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