A RARɣ agonist (EC50 = 30 nM in a transactivation assay); selective for RARɣ over RARβ (EC50 = 1

BMS 189961 – 10 mg

Brand:
Cayman
CAS:
185629-22-5
Storage:
-20
UN-No:
Non-Hazardous - /

BMS 189961 is an agonist of retinoic acid receptor ɣ (RARɣ; EC50 = 30 nM in a transactivation assay).{52154} It is selective for RARɣ over RARβ (EC50 = 1,000 nM). In vitro, BMS 189961 decreases long bone growth and digit formation of isolated mouse embryonic limb buds when used at concentrations of 0.01 and 0.1 µM.{52155} Topical administration of BMS 189661 (40 nmol) increases the skin expression of retinoid metabolism-related genes, including Rdh10, Crabp2, and Krt4, as well as epidermal barrier genes, including Spink5, Klk5, and Klk7, in mice.{52156}  

 

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SKU: 29380 - 10 mg Category:

Description

A RARɣ agonist (EC50 = 30 nM in a transactivation assay); selective for RARɣ over RARβ (EC50 = 1,000 nM in the same assay); decreases long bone growth and digit formation of isolated mouse embryonic limb buds in vitro at 0.01 and 0.1 µM; increases the skin expression of retinoid metabolism-related genes, including Rdh10, Crabp2, and Krt4, as well as epidermal barrier genes, including Spink5, Klk5, and Klk7 when applied topically to mice at 40 nmol

Formal name: 3-fluoro-4-[[2-hydroxy-2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)acetyl]amino]benzoic acid

Synonyms:  BMS 961

Molecular weight: 399.5

CAS: 185629-22-5

Purity: ≥98%

Formulation: A crystalline solid

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