A deoxyribonucleotide; formed via phosphorylation of deoxycytidine by deoxycytidine kinase in the cytosol or TK2 in mitochondria; phosphorylated by UMP-CMP kinase to form dCDP during nucleic acid synthesis; decreases hydroxyurea-induced neuroepithelial cell necrosis in embryonic mouse spinal cord when administered to pregnant dams at 700 mg/kg; oral administration in combination with dTMP increases lifespan in Tk2 H126N knock-in (Tk2-/-) mouse model of TK2 deficiency.

2′-Deoxycytidine-5′-monophosphate – 1 g

Brand:
Cayman
CAS:
1032-65-1
Storage:
-20
UN-No:
Non-Hazardous - /

2’-Deoxycytidine-5’-monophosphate (dCMP) is a deoxyribonucleotide.{48688} It is formed via phosphorylation of deoxycytidine by deoxycytidine kinase in the cytosol or thymidine kinase 2 (TK2) in mitochondria.{48672,48673} It is further phosphorylated by UMP-CMP kinase to form dCDP (Item No. 22982) during nucleic acid synthesis.{48674} dCMP (700 mg/kg) decreases hydroxyurea-induced neuroepithelial cell necrosis in embryonic mouse spinal cord when administered to pregnant dams.{48675} Oral administration of dCMP in combination with dTMP increases lifespan in Tk2 H126N knock-in (Tk2-/-) mouse model of TK2 deficiency.{48673}  

 

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SKU: 29340 - 1 g Category:

Description

A deoxyribonucleotide; formed via phosphorylation of deoxycytidine by deoxycytidine kinase in the cytosol or TK2 in mitochondria; phosphorylated by UMP-CMP kinase to form dCDP during nucleic acid synthesis; decreases hydroxyurea-induced neuroepithelial cell necrosis in embryonic mouse spinal cord when administered to pregnant dams at 700 mg/kg; oral administration in combination with dTMP increases lifespan in Tk2 H126N knock-in (Tk2-/-) mouse model of TK2 deficiency.

Formal name: 2′-deoxy-5′-cytidylic acid

Synonyms:  dCMP|Deoxycytidylate

Molecular weight: 307.2

CAS: 1032-65-1

Purity: ≥95%

Formulation: A solid

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