A thiazide diuretic; inhibits sodium and chloride ion flux in the connecting tubule

Trichlormethiazide – 1 g

Brand:
Cayman
CAS:
133-67-5
Storage:
-20
UN-No:
Non-Hazardous - /

Trichlormethiazide is a thiazide diuretic.{49458} It inhibits sodium and chloride ion flux in the connecting tubule, but not the cortical collecting duct or the distal convoluted tubule, in isolated rabbit kidney tubules when used at a concentration of 1 mM. Trichlormethiazide increases relaxation induced by acetylcholine (Item No. 23829) in norepinephrine-precontracted mesenteric arterial rings isolated from spontaneously hypertensive rats (EC50 = 33 nM).{49459} It increases urine output and urinary excretion of sodium, potassium, and chloride ions in dogs in a dose-dependent manner.{49461} It reduces systolic blood pressure in spontaneously hypertensive, but not normotensive, rats when administered at doses of 10 and 30 mg/kg.{49461} Formulations containing trichlormethiazide have been used in the treatment of edema and hypertension.  

 

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SKU: 29331 - 1 g Category:

Description

A thiazide diuretic; inhibits sodium and chloride ion flux in the connecting tubule, but not the cortical collecting duct or the distal convoluted tubule, in isolated rabbit kidney tubules at 1 mM; increases acetylcholine-induced relaxation in norepinephrine-precontracted mesenteric arterial rings isolated from spontaneously hypertensive rats (EC50 = 33 nM); increases urine output and urinary excretion of sodium, potassium, and chloride ions in dogs in a dose-dependent manner; reduces systolic blood pressure in spontaneously hypertensive, but not normotensive, rats at 10 and 30 mg/kg

Formal name: 6-chloro-3-(dichloromethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide, 1,1-dioxide

Synonyms: 

Molecular weight: 380.7

CAS: 133-67-5

Purity: ≥98%

Formulation: A solid

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