Description
An inhibitor of norepinephrine and dopamine reuptake; inhibits uptake of NE, DA, and 5-HT in rat brain synaptosomes (IC50s = 6.6, 48, and 830 nM, respectively); selective for DA, NE, and 5-HT uptake inhibition over binding to dopamine D2, α1- adrenergic-, 5-HT2, and muscarinic receptors (IC50s = 43,000, 1,200, 3,800, and >13,000 nM, respectively, in rat brain membranes); is selective for inhibition of NE over DA uptake in vivo with minimal inhibitory doses of 28 and < 57 µmol/kg, respectively; decreases the time Wistar Kyoto, but not Sprague-Dawley, rats spend immobile in the forced swim test but also increases locomotor activity in the open field test in Wistar Kyoto and Sprague-Dawley rats at 10 mg/kg
Formal name: 1,2,3,4-tetrahydro-2-methyl-4-phenyl-8-isoquinolinamine
Synonyms: (±)-Nomifensine
Molecular weight: 238.3
CAS: 24526-64-5
Purity: ≥95%
Formulation: A crystalline solid
