A thymidylate synthase inhibitor (Ki = 11 nM); inhibits cell growth in a panel of human and murine cancer cell lines (IC50s = 0.39-6.6 μM); inhibits the growth of L1210 cells

Nolatrexed (hydrochloride) – 10 mg

Brand:
Cayman
CAS:
152946-68-4
Storage:
-20
UN-No:
Non-Hazardous - /

Nolatrexed is a thymidylate synthase inhibitor (Ki = 11 nM).{46592} It inhibits cell growth in a panel of human and murine cancer cell lines (IC50s = 0.39-6.6 μM). Nolatrexed inhibits the growth of L1210 cells, an effect that is decreased by greater than 50-fold by the addition of exogenous thymidine. Nolatrexed (0.7 and 3.5 μM) induces cell cycle arrest at the S phase in L1210 cells. It increases life span in a thymidine kinase-deficient L5178Y/TK- murine lymphoma model when administered at doses ranging from 25 to 200 mg/kg.  

 

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SKU: 29247 - 10 mg Category:

Description

A thymidylate synthase inhibitor (Ki = 11 nM); inhibits cell growth in a panel of human and murine cancer cell lines (IC50s = 0.39-6.6 μM); inhibits the growth of L1210 cells, an effect that is decreased by greater than 50-fold by the addition of exogenous thymidine; induces cell cycle arrest at the S phase in L1210 cells at 0.7 and 3.5 μM; increases life span in a thymidine kinase-deficient L5178Y/TK- murine lymphoma model at 25-200 mg/kg

Formal name: 2-amino-6-methyl-5-(4-pyridinylthio)-4(1H)-quinazolinone, dihydrochloride

Synonyms:  AG337

Molecular weight: 357.3

CAS: 152946-68-4

Purity: ≥98%

Formulation: A crystalline solid

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