A chemical activator that has been commonly used in solid-phase synthesis of DNA and RNA oligonucleotides; catalyzes the phosphoramidite coupling reaction of the 5' hydroxy of immobilized nucleosides and the amine group of nucleoside phosphoramidite; has been used to synthesize ssDNA oligonucleotides that are resistant to nuclease digestion

Saccharin 1-methylimidazole – 5 mg

Brand:
Cayman
CAS:
482333-74-4
Storage:
-20
UN-No:
De Minimis - 3077 / 9

Saccharin 1-methylimidazole is a chemical activator that has been commonly used in solid-phase synthesis of DNA and RNA oligonucleotides.{46594} It catalyzes the phosphoramidite coupling reaction of the 5′ hydroxy of immobilized nucleosides and the amine group of nucleoside phosphoramidite. Saccharin 1-methylimidazole has been used to synthesize single-stranded DNA (ssDNA) oligonucleotides that are resistant to nuclease digestion.{46595}  

 

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SKU: 29242 - 5 mg Category:

Description

A chemical activator that has been commonly used in solid-phase synthesis of DNA and RNA oligonucleotides; catalyzes the phosphoramidite coupling reaction of the 5′ hydroxy of immobilized nucleosides and the amine group of nucleoside phosphoramidite; has been used to synthesize ssDNA oligonucleotides that are resistant to nuclease digestion

Formal name: benzo[d]isothiazol-3(2H)-one 1,1-dioxide, 1-methyl-1H-imidazole

Synonyms: 

Molecular weight: 265.3

CAS: 482333-74-4

Purity: ≥98%

Formulation: A solid

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