A dual inhibitor of PI3K and mTOR (IC50s = 2.0

NSC 781406 – 1 mg

Brand:
Cayman
CAS:
1676893-24-5
Storage:
-20
UN-No:
Non-Hazardous - /

NSC 781406 is a dual inhibitor of PI3K and mammalian target of rapamycin (mTOR; IC50s = 2.0, 9.4, 2.7, 14, and 5.4 nM for PI3Kα, PI3Kβ, PI3Kγ, PI3Kδ, and mTOR, respectively).{52165} It inhibits cell growth in the NCI-60 panel of cancer cell lines (mean GI50 = 65 nM). NSC 781406 (30 mg/kg) reduces tumor volume in a BEL-7404 hepatic cancer mouse xenograft model.  

 

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SKU: 29226 - 1 mg Category:

Description

A dual inhibitor of PI3K and mTOR (IC50s = 2.0, 9.4, 2.7, 14, and 5.4 nM for PI3Kα, PI3Kβ, PI3Kγ, PI3Kδ, and mTOR, respectively); inhibits cell growth in the NCI-60 panel of cancer cell lines (mean GI50 = 65 nM); reduces tumor volume in a BEL-7404 hepatic cancer mouse xenograft model at 30 mg/kg

Formal name: 2,4-difluoro-N-[2-methoxy-5-[4-[3-[4-(methylsulfonyl)-1-piperazinyl]-1-propyn-1-yl]-6-quinolinyl]-3-pyridinyl]-benzenesulfonamide

Synonyms: 

Molecular weight: 627.7

CAS: 1676893-24-5

Purity: ≥98%

Formulation: A solid

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