A mGluR1 antagonist (IC50 = 5.1 nM for the human receptor); selective for mGluR1 over mGluR2

FITM – 1 mg

Brand:
Cayman
CAS:
932737-65-0
Storage:
-20
UN-No:
Non-Hazardous - /

FITM is an antagonist of metabotropic glutamate receptor 1 (mGluR1; IC50 = 5.1 nM for the human receptor).{46556} It is selective for mGluR1 over mGluR2, mGluR5, and mGluR8 (IC50s = >10, 7, and >10 µM, respectively). FITM (0.3 mg/kg) decreases methamphetamine-induced hyperlocomotion in mice and reverses disruptions in prepulse inhibition induced by methamphetamine and ketamine in rats when administered at a dose of 1 mg/kg.  

 

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SKU: 29219 - 1 mg Category:

Description

A mGluR1 antagonist (IC50 = 5.1 nM for the human receptor); selective for mGluR1 over mGluR2, mGluR5, and mGluR8 (IC50s = >10, 7, and >10 µM, respectively); decreases methamphetamine-induced hyperlocomotion in mice at 0.3 mg/kg and reverses disruptions in prepulse inhibition induced by methamphetamine and ketamine in rats at 1 mg/kg

Formal name: 4-fluoro-N-methyl-N-[4-[6-[(1-methylethyl)amino]-4-pyrimidinyl]-2-thiazolyl]-benzamide

Synonyms: 

Molecular weight: 371.4

CAS: 932737-65-0

Purity: ≥98%

Formulation: A crystalline solid

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