An inhibitor of menin-MLL fusion protein interactions (IC50 = 446 nM); binds to menin (Kd = 158 nM) and inhibits the menin-MLL-AF9 interaction in HEK293 cells; inhibits growth of mouse BMCs expressing the Hoxa9 transformation-dependent MLL-AF9 (GI50 = 5 µM); inhibits the growth of MV4

MI-2 – 25 mg

Brand:
Cayman
CAS:
1271738-62-5
Storage:
-20
UN-No:
Non-Hazardous - /

MI-2 is an inhibitor of the protein-protein interaction between menin and mixed lineage leukemia (MLL) fusion proteins (IC50 = 446 nM).{20716} It binds to menin (Kd = 158 nM) and inhibits the menin interaction with the MLL fusion protein MLL-AF9 in HEK293 cells without affecting protein levels of menin or MLL-AF9. MI-2 inhibits the growth of mouse bone marrow cells (BMCs) expressing the Hoxa9 transformation-dependent MLL-AF9 (GI50 = 5 μM). It also inhibits the growth of MV4, KOPN-8, ML-2, and MonoMac6 MLL cells expressing MLL fusion proteins (GI50s = 9.5, 7.2, 8.7, and 18 μM, respectively), as well as induces hematopoietic differentiation.  

 

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SKU: 29218 - 25 mg Category:

Description

An inhibitor of menin-MLL fusion protein interactions (IC50 = 446 nM); binds to menin (Kd = 158 nM) and inhibits the menin-MLL-AF9 interaction in HEK293 cells; inhibits growth of mouse BMCs expressing the Hoxa9 transformation-dependent MLL-AF9 (GI50 = 5 µM); inhibits the growth of MV4, KOPN-8, ML-2, and MonoMac6 MLL cells expressing MLL fusion proteins (GI50s = 9.5, 7.2, 8.7, and 18 μM, respectively)

Formal name: 4-[4-(4,5-dihydro-5,5-dimethyl-2-thiazolyl)-1-piperazinyl]-6-propyl-thieno[2,3-d]pyrimidine

Synonyms: 

Molecular weight: 375.6

CAS: 1271738-62-5

Purity: ≥98%

Formulation: A crystalline solid

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