A CRF1 antagonist (IC50 = 5.1 nM); inhibits adenylate cyclase activity stimulated by ovine CRF in rat cerebral cortex and at human CRF1 receptors; inhibits CRF-induced increases in the acoustic startle response in rats at 17.8 mg/kg; increases the percentage of open arm entries and time spent in the open arms of the elevated plus maze in mice at 1.5 and 3 nmol; reduces ethanol consumption in rats trained on an intermittent access schedule at 10 mg/kg; increases pulmonary ventilation in rats under normocapnic and hypercapnic conditions at 5 nmol/0.1 μl

CP 376,395 – 5 mg

Brand:
Cayman
CAS:
175140-00-8
Storage:
-20
UN-No:
Non-Hazardous - /

CP 376,395 is an antagonist of corticotropin-releasing factor (CRF) receptor 1 (CRF1; IC50 = 5.1 nM).{52114} It inhibits adenylate cyclase activity stimulated by ovine CRF in rat cerebral cortex and at human CRF1 receptors. CP 376,395 (17.8 mg/kg) inhibits CRF-induced increases in the acoustic startle response in rats. It increases the percentage of open arm entries and time spent in the open arms of the elevated plus maze in mice when administered via intramedial prefrontal cortical injection at doses of 1.5 and 3 nmol.{52113} CP 376,395 (10 mg/kg) reduces ethanol consumption in rats trained on an intermittent access schedule.{52112} It increases pulmonary ventilation in rats under normocapnic and hypercapnic conditions when injected into the locus coeruleus at a dose of 5 nmol/0.1 μl.{52111}  

 

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SKU: 29188 - 5 mg Category:

Description

A CRF1 antagonist (IC50 = 5.1 nM); inhibits adenylate cyclase activity stimulated by ovine CRF in rat cerebral cortex and at human CRF1 receptors; inhibits CRF-induced increases in the acoustic startle response in rats at 17.8 mg/kg; increases the percentage of open arm entries and time spent in the open arms of the elevated plus maze in mice at 1.5 and 3 nmol; reduces ethanol consumption in rats trained on an intermittent access schedule at 10 mg/kg; increases pulmonary ventilation in rats under normocapnic and hypercapnic conditions at 5 nmol/0.1 μl

Formal name: N-(1-ethylpropyl)-3,6-dimethyl-2-(2,4,6-trimethylphenoxy)-4-pyridinamine

Synonyms:  CP 316311

Molecular weight: 326.5

CAS: 175140-00-8

Purity: ≥98%

Formulation: A crystalline solid

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