Description
A CRF1 antagonist (IC50 = 5.1 nM); inhibits adenylate cyclase activity stimulated by ovine CRF in rat cerebral cortex and at human CRF1 receptors; inhibits CRF-induced increases in the acoustic startle response in rats at 17.8 mg/kg; increases the percentage of open arm entries and time spent in the open arms of the elevated plus maze in mice at 1.5 and 3 nmol; reduces ethanol consumption in rats trained on an intermittent access schedule at 10 mg/kg; increases pulmonary ventilation in rats under normocapnic and hypercapnic conditions at 5 nmol/0.1 μl
Formal name: N-(1-ethylpropyl)-3,6-dimethyl-2-(2,4,6-trimethylphenoxy)-4-pyridinamine
Synonyms: CP 316311
Molecular weight: 326.5
CAS: 175140-00-8
Purity: ≥98%
Formulation: A crystalline solid
