A potent COMT inhibitor (IC50 = 12 nM); selective for COMT over tyrosine hydroxylase

3,5-Dinitrocatechol – 5 mg

Brand:
Cayman
CAS:
7659-29-2
Storage:
-20
UN-No:
Non-Hazardous - /

3,5-Dinitrocatechol is a potent catechol O-methyltransferase (COMT) inhibitor (IC50 = 12 nM).{46554} It is selective for COMT over tyrosine hydroxylase, dopamine β-hydroxylase, dopamine decarboxylase, monoamine oxidase A (MAO-A), and MAO-B (IC50s = >14 μM for all). 3,5-Dintrocatechol (30 mg/kg), in combination with L-DOPA (Item No. 13248) and carbidopa (Item No. 23783), reduces 3-O-methyldopa (3-OMD) levels in rat serum, compared with control animals receiving only L-DOPA and carbidopa. Chronic administration of 3,5-dinitrocatechol (15 mg/kg per day for seven days) induces COMT-dependent thermal hyperalgesia and increases preference for dark in a light/dark preference test, indicating anxiety-like behavior, in rats, effects that can be prevented by the β-adrenergic receptor antagonist propranolol (Item No. 23349).{46555}  

 

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SKU: 29180 - 5 mg Category:

Description

A potent COMT inhibitor (IC50 = 12 nM); selective for COMT over tyrosine hydroxylase, dopamine β-hydroxylase, dopamine decarboxylase, MAO-A, and MAO-B (IC50s = >14 μM for all); reduces 3-OMD levels in rat serum when administered in combination with L-DOPA and carbidopa compared with control animals receiving only L-DOPA and carbidopa at 30 mg/kg; chronic administration induces COMT-dependent thermal hyperalgesia and increases preference for dark in a light/dark preference test in rats at 15 mg/kg per day for seven days

Formal name: 3,5-dinitro-1,2-benzenediol

Synonyms:  OR-486

Molecular weight: 200.1

CAS: 7659-29-2

Purity: ≥98%

Formulation: A crystalline solid

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